2-CHLORO-4-IODO-1-METHOXYBENZENE → HCID 67047660, compound

HRID 606863Notes

Reaction equation

HRID 606863 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](I)[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].C[Si]([C:15]#[C:16][C:17]1[CH:18]=[N:19][CH:20]=[C:21]([CH:24]=1)[C:22]#[N:23])(C)C>>[Cl:1][C:2]1[CH:7]=[C:6]([C:15]#[C:16][C:17]2[CH:18]=[N:19][CH:20]=[C:21]([CH:24]=2)[C:22]#[N:23])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 111847502-CHLORO-4-IODO-1-METHOXYBENZENEHCID 161156995-[2-(Trimethylsilyl)ethynyl]pyridine-3-carbonitrile

Product 1

HCID 67047660HCID 67047660, compoundYield 174.4%

Procedure

Prepare according to the general procedure outlined in EXAMPLE 72 using 2-chloro-4-iodo-1-methoxybenzene (520 mg, 19 mmol) and 5-trimethylsilanylethynyl-nicotinonitrile (350 mg, 1.75 mmol), (prepared as described in PREPARATION 3), to give the title compound (820 mg, 47%).

Workup

  1. customPrepare

Sources & evidence

ORD record
ord-b4898ee671af4d5ab44e52e0527d46be
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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