反应详情

To a solution of 32.7 g (146 mmol) of 4-(5-chloropentoxy) benzonitrile in 350 mL acetone is added 38.3 g (150 mmol) of sodium iodide in 230 mL of acetone. The reaction is heated to reflux and stirred overnight. The acetone is removed under reduced pressure and the residue partitioned between water and ether. The ethereal layer is dried, filtered and evaporated to give 4-(5-iodopentoxy) benzonitrile, m.p. 51°-54° C.

1. temperatureThe reaction is heated
2. temperatureto reflux
3. customThe acetone is removed under reduced pressure
4. customthe residue partitioned between water and ether
5. customThe ethereal layer is dried
6. filtrationfiltered
7. customevaporated