Methyl chloroformate → HCID 67047779, compound

HRID 606901Notes

Reaction equation

HRID 606901 reaction equation
Cl.[F:2][C:3]([F:20])([F:19])[C:4]1[CH:5]=[C:6]([C:10]#[C:11][C:12]2[CH:13]=[C:14]([NH2:18])[CH:15]=[N:16][CH:17]=2)[CH:7]=[CH:8][CH:9]=1.Cl[C:22]([O:24][CH3:25])=[O:23]>>[CH3:25][O:24][C:22](=[O:23])[NH:18][C:14]1[CH:15]=[N:16][CH:17]=[C:12]([C:11]#[C:10][C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([C:3]([F:2])([F:19])[F:20])[CH:5]=2)[CH:13]=1

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 67048040HCID 67048040, compound

Product 1

HCID 67047779HCID 67047779, compoundYield 49%

Procedure

Prepare essentially as described in EXAMPLE 158 using 5-(3-trifluoromethylphenylethynyl)-pyridin-3-ylamine hydrochloride, (prepared as described in EXAMPLE 155), (151 mg, 0.45 mmol) and methyl chloroformate (0.03 mL, 0.45 mmol) to give the title compound (70 mg, 49%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-ed0cd82f9e304c5ca53fc9de592d9efa
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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