HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Phenylethynyl-pyridin-3-ylamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (5-Phenylethynyl-pyridin-3-yl)-carbamic acid tert-butyl ester | HCID 49855802 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Phenylethynyl-pyridin-3-ylamine dihydrochloride | HCID 67047697 | 81% |
Reaction Steps
Prepare essentially as described in EXAMPLE 2 from 5-phenylethynyl-pyridin-3-yl)-carbamic acid tert-butyl ester, (prepared as described in EXAMPLE 154), (0.380 g, 1.3 mmol) in 1,4-dioxane (1 mL) and hydrogen chloride (3 mL, 12 mmol) to give the title compound (280 mg, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-a57a3929e4f14f7da9009757dc40441e |
| Source note | uspto-grants-2011_03 |