Hydrochloric Acid → 5-Phenylethynyl-pyridin-3-ylamine dihydrochloride

HRID 606919Notes

Reaction equation

HRID 606919 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:13]=1)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[ClH:23].[C:16]1([C:15]#[C:14][C:12]2[CH:13]=[C:8]([NH2:7])[CH:9]=[N:10][CH:11]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49855802(5-Phenylethynyl-pyridin-3-yl)-carbamic acid tert-butyl ester

Product 1

HCID 670476975-Phenylethynyl-pyridin-3-ylamine dihydrochlorideYield 81%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepare essentially as described in EXAMPLE 2 from 5-phenylethynyl-pyridin-3-yl)-carbamic acid tert-butyl ester, (prepared as described in EXAMPLE 154), (0.380 g, 1.3 mmol) in 1,4-dioxane (1 mL) and hydrogen chloride (3 mL, 12 mmol) to give the title compound (280 mg, 81%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-a57a3929e4f14f7da9009757dc40441e
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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