4-Bromo-1-fluoro-2-nitrobenzene → HCID 67047647, compound

HRID 606923Notes

Reaction equation

HRID 606923 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[C:12]([C:14]1[CH:15]=[N:16][CH:17]=[C:18]([CH:21]=1)[C:19]#[N:20])#[CH:13]>>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:13]#[C:12][C:14]2[CH:15]=[N:16][CH:17]=[C:18]([CH:21]=2)[C:19]#[N:20])=[CH:3][C:4]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 27363284-Bromo-1-fluoro-2-nitrobenzeneHCID 224165635-Ethynylnicotinonitrile

Product 1

HCID 67047647HCID 67047647, compoundYield 9.1%

Procedure

Prepare essentially as described in EXAMPLE 142 using 4-bromo-1-fluoro -2-nitrobenzene (1.0 g, 4.5 mmol) and 5-ethynylnicotinonitrile, (prepared as described in PREPARATION 4), (0.7 g, 5.5 mmol) to give the title compound as a yellow solid (0.11 g, 9%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-58b4211942c947a48ba15e398837dbcc
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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