反应详情

A mixture of the product of Example 8a (1.50 g, 5.97 mmol) and diphenyl ether (25 mL) was heated under reflux for 1 h, with removal of the resultant acetone by distillation. The solvent was then decanted, and the remaining solid residue was dissolved in dichloromethane (5 mL) and purified by chromatography on silica gel, eluting with a 0-10% MeOH/CH2Cl2 gradient, to provide the title compound (0.360 g, 40% yield).

1. temperaturewas heated
2. customThe solvent was then decanted
3. dissolutionthe remaining solid residue was dissolved in dichloromethane (5 mL)
4. custompurified by chromatography on silica gel
5. washeluting with a 0-10% MeOH/CH2Cl2 gradient