Dimethylformamide dimethyl acetal → N'-(2-Benzylsulfanyl-5-cyano-pyrimidin-4-yl)-N,N-dimethyl-formamidine

HRID 607276Notes

Reaction equation

HRID 607276 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([S:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1.CO[CH:20](OC)[N:21]([CH3:23])[CH3:22].C(C1C(N=CN(C)C)=NC(SCC)=NC=1)#N>>[CH2:11]([S:10][C:4]1[N:3]=[C:2]([N:1]=[CH:20][N:21]([CH3:23])[CH3:22])[C:7]([C:8]#[N:9])=[CH:6][N:5]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 78373Dimethylformamide dimethyl acetalHCID 2958834-Amino-2-benzylsulfanylpyrimidine-5-carbonitrile2×HCID 66808651N'-(5-Cyano-2-ethylsulfanyl-pyrimidin-4-yl)-N,N-dimethyl-formamidine

Product 1

HCID 66808495N'-(2-Benzylsulfanyl-5-cyano-pyrimidin-4-yl)-N,N-dimethyl-formamidine

Procedure

A solution of the product from Example 183B was reacted with N,N-dimethylformamide dimethyl acetal according to the procedure from Example 156B substituting the product from Example 183B for the product from Example 156B to provide the title compound.

Sources & evidence

ORD record
ord-ac9ce5a1c2e94b61946f4741f1e1ebbb
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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