3-Nitrophenol → HCID 20116860, compound

HRID 607287Notes

Reaction equation

HRID 607287 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-])=O.Br[CH2:12][C:13]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=1.BrCC1C=CC=C(F)C=1>>[NH2:1][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:12][C:13]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 111373-NitrophenolHCID 680073-Fluorobenzyl bromideHCID 869964-(Bromomethyl)benzonitrile

Product 1

HCID 20116860HCID 20116860, compound

Procedure

3-Nitro-phenol was reacted with 4-bromomethyl-benzonitrile according to the procedure from Example 199A substituting 4-bromomethyl-benzonitrile for 1-bromomethyl-3-fluoro-benzene then reduced according to the procedure from Example 199B to provide the title compound.

Sources & evidence

ORD record
ord-bdfcb8c5261b4a8fbf207fa5d533649a
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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