Benzyl Bromide → 3-Benzyloxyaniline

HRID 607290Notes

Reaction equation

HRID 607290 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-])=O.Br[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.BrCC1C=CC=C(F)C=1>>[CH2:12]([O:10][C:6]1[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 111373-NitrophenolHCID 680073-Fluorobenzyl bromide

Product 1

HCID 928923-Benzyloxyaniline

Procedure

3-Nitro-phenol was reacted with bromomethyl-benzene according to the procedure from Example 199A substituting bromomethyl-benzene for 1-bromomethyl-3-fluoro-benzene then reduced according to the procedure from Example 199B to provide the title compound.

Sources & evidence

ORD record
ord-6198c75e4d9d476491564a7a5aa76fbd
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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