Dimethylformamide dimethyl acetal → N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidine

HRID 607328Notes

Reaction equation

HRID 607328 reaction equation
[NH2:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][CH:5]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:11]([C:3]1[C:2]([N:1]=[CH:15][N:16]([CH3:18])[CH3:17])=[N:7][C:6]([CH:8]([CH3:10])[CH3:9])=[CH:5][N:4]=1)#[N:12]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 451224093-Amino-5-isopropylpyrazine-2-carbonitrile

Product 1

HCID 66808405N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidineYield 100.9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of the product from Example 244B (0.37 g, 2.28 mmol) and dimethylformamide dimethylacetal (0.30 g, 2.5 mmol, 1.1 eq) in toluene (25 mL) was heated under reflux for 1.75 h. The reaction mixture was then cooled to room temperature and the solvent evaporated under reduced pressure to provide the title compound (0.50 g, 100%) as a thick red/brown oil that was used in subsequent reactions without further purification.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1.75 h
  3. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-85a837887aca4eb4bebd7c9770ff41fd
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

Loading…