反应详情

To a solution of 3-iodoaniline (131 mg, 0.60 mmol) in 1.5 ml pyridine at room temperature was added over 2 minutes a solution of 1,3-dimethylpyrazole-5-carbonyl chloride (79 mg, 0.50 mmol) in 0.3 ml 1,2-dichloroethane. The reaction was stirred at room temperature for 30 minutes, quenched into a NaHCO3 solution, and extracted into EtOAc. The EtOAc solution was washed with NaHCO3 solution, brine, dried with anhydrous Na2SO4 and rotary evaporated. The resultant gummy solid was recrystallized from hexane/EtOAc to give the title compound as solid white needles (135 mg, 80%).

1. customquenched into a NaHCO3 solution
2. extractionextracted into EtOAc
3. washThe EtOAc solution was washed with NaHCO3 solution, brine
4. dry with materialdried with anhydrous Na2SO4 and rotary evaporated
5. customThe resultant gummy solid was recrystallized from hexane/EtOAc