2-Morpholinoethylamine → 5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]-N-[methyl(3-{2-[(2-morpholin-4-ylethyl)amino]-2-oxoethyl}phenyl)oxido--sulfanylidene]nicotinamide

HRID 607443Notes

Reaction equation

HRID 607443 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([NH:9][C:10]2[CH:11]=[C:12]([C:16]#[C:17][C:18]3[CH:19]=[C:20]([C:24]([N:26]=[S:27]([C:30]4[CH:31]=[C:32]([CH2:36][C:37](O)=[O:38])[CH:33]=[CH:34][CH:35]=4)([CH3:29])=[O:28])=[O:25])[CH:21]=[N:22][CH:23]=3)[CH:13]=[CH:14][CH:15]=2)=[O:8])=[CH:5][C:4]([CH3:40])=[N:3]1.[NH2:41][CH2:42][CH2:43][N:44]1[CH2:49][CH2:48][O:47][CH2:46][CH2:45]1>>[CH3:1][N:2]1[C:6]([C:7]([NH:9][C:10]2[CH:11]=[C:12]([C:16]#[C:17][C:18]3[CH:23]=[N:22][CH:21]=[C:20]([CH:19]=3)[C:24]([N:26]=[S:27]([CH3:29])([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([CH2:36][C:37]([NH:41][CH2:42][CH2:43][N:44]4[CH2:49][CH2:48][O:47][CH2:46][CH2:45]4)=[O:38])[CH:31]=3)=[O:28])=[O:25])[CH:13]=[CH:14][CH:15]=2)=[O:8])=[CH:5][C:4]([CH3:40])=[N:3]1

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 57657964{3-[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]phenyl}acetic acid

Product 1

HCID 576578425-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]-N-[methyl(3-{2-[(2-morpholin-4-ylethyl)amino]-2-oxoethyl}phenyl)oxido--sulfanylidene]nicotinamideYield 54%

Procedure

In a manner similar to that described in Example 500, {3-[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]phenyl}acetic acid and 4-(2-aminoethyl)morpholine were reacted to give the title compound (54%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b04e5cdc61ae44e2ae1f80e5d920ac56
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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