HRID607466

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57657904

未命名化合物

结构：CC(C)(C)[Si](C)(C)OCCC[S@@](=O)(=NC(=O)c1cncc(Br)c1)c1ccccc1

HCID86629482

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C(=O)Nc2cccc(C#Cc3cncc(C(=O)N=[S@](=O)(CCCO[Si](C)(C)C(C)(C)C)c4ccccc4)c3)c2)n(C)n1

HCID57657857

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described in Example 506 (step 3), (S)-5-bromo-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl--sulfanylidene]nicotinamide and N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide are converted to the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7caacd93a0ea4f6082b89beece6787ab
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07915443B2
来源说明: uspto-grants-2011_03

反应 SMILES

Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:29]=1)[C:7]([N:9]=[S@@:10]([CH2:18][CH2:19][CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].[C:30]([C:32]1[CH:33]=[C:34]([NH:38][C:39]([C:41]2[N:45]([CH3:46])[N:44]=[C:43]([CH3:47])[CH:42]=2)=[O:40])[CH:35]=[CH:36][CH:37]=1)#[CH:31]>>[Si:22]([O:21][CH2:20][CH2:19][CH2:18][S@:10](=[O:17])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[N:9][C:7](=[O:8])[C:6]1[CH:29]=[C:2]([C:31]#[C:30][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([NH:38][C:39]([C:41]3[N:45]([CH3:46])[N:44]=[C:43]([CH3:47])[CH:42]=3)=[O:40])[CH:33]=2)[CH:3]=[N:4][CH:5]=1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]