HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide → (S)-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl--sulfanylidene]-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide | HCID 57657904 | — |
| Reactant | (S)-5-bromo-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl--sulfanylidene]nicotinamide | HCID 86629482 | — |
| Product | (S)-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl--sulfanylidene]-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinamide | HCID 57657857 | — |
Reaction Steps
In a manner similar to that described in Example 506 (step 3), (S)-5-bromo-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl--sulfanylidene]nicotinamide and N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide are converted to the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915443B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-7caacd93a0ea4f6082b89beece6787ab |
| Source note | uspto-grants-2011_03 |