HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → (S)-N-{[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | (S)-ethyl(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate | HCID 86629488 | — |
| Product | (S)-N-{[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 57657932 | — |
Reaction Steps
In a manner similar to that described in Example 534, (S)-Ethyl(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate and 4-hydroxypiperidine were reacted to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915443B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-56b4fc09d4d64ae5b14a8a1507d23fbd |
| Source note | uspto-grants-2011_03 |