Piperidin-4-ol → (S)-N-{[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

HRID 607472Notes

Reaction equation

HRID 607472 reaction equation
C([C@H:3]([S:7]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)(=[N:9][C:10]([C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]#[C:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:27]([C:29]3[O:30][CH:31]=[CH:32][C:33]=3[CH3:34])=[O:28])[CH:21]=2)[CH:17]=1)=[O:11])=[O:8])[C:4]([O-])=[O:5])C.[OH:41][CH:42]1[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1>>[OH:41][CH:42]1[CH2:47][CH2:46][N:45]([C:4](=[O:5])[CH2:3][S@:7](=[O:8])([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)=[N:9][C:10](=[O:11])[C:12]2[CH:17]=[C:16]([C:18]#[C:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:27]([C:29]4[O:30][CH:31]=[CH:32][C:33]=4[CH3:34])=[O:28])[CH:21]=3)[CH:15]=[N:14][CH:13]=2)[CH2:44][CH2:43]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 86629488(S)-ethyl(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate

Product 1

HCID 57657932(S)-N-{[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

Procedure

In a manner similar to that described in Example 534, (S)-Ethyl(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate and 4-hydroxypiperidine were reacted to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-56b4fc09d4d64ae5b14a8a1507d23fbd
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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