Pyrrolidine → (S)-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)-N-[oxido(2-oxo-2-pyrrolidin-1-ylethyl)phenyl--sulfanylidene]nicotinamide

HRID 607473Notes

Reaction equation

HRID 607473 reaction equation
C([C@H:3]([S:7]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)(=[N:9][C:10]([C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]#[C:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:27]([C:29]3[O:30][CH:31]=[CH:32][C:33]=3[CH3:34])=[O:28])[CH:21]=2)[CH:17]=1)=[O:11])=[O:8])[C:4]([O-])=[O:5])C.[NH:41]1[CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH3:34][C:33]1[CH:32]=[CH:31][O:30][C:29]=1[C:27]([NH:26][C:22]1[CH:21]=[C:20]([C:19]#[C:18][C:16]2[CH:15]=[N:14][CH:13]=[C:12]([CH:17]=2)[C:10]([N:9]=[S@:7](=[O:8])([CH2:3][C:4](=[O:5])[N:41]2[CH2:45][CH2:44][CH2:43][CH2:42]2)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:11])[CH:25]=[CH:24][CH:23]=1)=[O:28]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 86629488(S)-ethyl(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate

Product 1

HCID 57657894(S)-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)-N-[oxido(2-oxo-2-pyrrolidin-1-ylethyl)phenyl--sulfanylidene]nicotinamide

Procedure

In a manner similar to that described in Example 534, (S)-Ethyl(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate and pyrrolidine were reacted to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c0e65082f2c54b81a72681f9623ddef3
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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