HRID607486

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)Cc1cccc(S(C)(=O)=NC(=O)C(F)(F)F)c1

HCID57657827

未命名化合物

结构：Cc1cc(C(=O)Nc2cccc(C#Cc3cc(C(=O)O)cnc3N)c2)n(C)n1

HCID57657867

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Cc1cccc(S(C)(=O)=NC(=O)c2cnc(N)c(C#Cc3cccc(NC(=O)c4cc(C)nn4C)c3)c2)c1

HCID57657942

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described in Example 496 (step 5), 6-amino-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinic acid and methyl{3-[S-methyl-N-(trifluoroacetyl)sulfonimidoyl]phenyl}acetate were reacted to give the title compound.

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-55ebc3c95f764e4389a17fa510678c18
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07915443B2
来源说明: uspto-grants-2011_03

反应 SMILES

[NH2:1][C:2]1[C:10]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]3[N:26]([CH3:27])[N:25]=[C:24]([CH3:28])[CH:23]=3)=[O:21])[CH:14]=2)=[CH:9][C:5](C(O)=O)=[CH:4][N:3]=1.[CH3:29][O:30][C:31](=[O:49])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([S:39]([CH3:48])(=[N:41][C:42](=[O:47])C(F)(F)F)=[O:40])[CH:34]=1>>[CH3:29][O:30][C:31](=[O:49])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([S:39]([CH3:48])(=[N:41][C:42]([C:5]2[CH:4]=[N:3][C:2]([NH2:1])=[C:10]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]4[N:26]([CH3:27])[N:25]=[C:24]([CH3:28])[CH:23]=4)=[O:21])[CH:14]=3)[CH:9]=2)=[O:47])=[O:40])[CH:34]=1