Methyl{3-[s-methyl-n-(trifluoroacetyl)sulfonimidoyl]phenyl}acetate → methyl {3-[N-({6-amino-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]phenyl}acetate

HRID 607486Notes

Reaction equation

HRID 607486 reaction equation
[NH2:1][C:2]1[C:10]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]3[N:26]([CH3:27])[N:25]=[C:24]([CH3:28])[CH:23]=3)=[O:21])[CH:14]=2)=[CH:9][C:5](C(O)=O)=[CH:4][N:3]=1.[CH3:29][O:30][C:31](=[O:49])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([S:39]([CH3:48])(=[N:41][C:42](=[O:47])C(F)(F)F)=[O:40])[CH:34]=1>>[CH3:29][O:30][C:31](=[O:49])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([S:39]([CH3:48])(=[N:41][C:42]([C:5]2[CH:4]=[N:3][C:2]([NH2:1])=[C:10]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]4[N:26]([CH3:27])[N:25]=[C:24]([CH3:28])[CH:23]=4)=[O:21])[CH:14]=3)[CH:9]=2)=[O:47])=[O:40])[CH:34]=1

Participants

3

Reactant 2

HCID 57657827Methyl{3-[s-methyl-n-(trifluoroacetyl)sulfonimidoyl]phenyl}acetateHCID 576578676-Amino-5-{3-[(2,5-dimethyl-2H-pyrazole-3-carbonyl)-amino]-phenylethynyl}-nicotinic acid

Product 1

HCID 57657942methyl {3-[N-({6-amino-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]phenyl}acetate

Procedure

In a manner similar to that described in Example 496 (step 5), 6-amino-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinic acid and methyl{3-[S-methyl-N-(trifluoroacetyl)sulfonimidoyl]phenyl}acetate were reacted to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-55ebc3c95f764e4389a17fa510678c18
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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