Pyrrolidine → 2-(Pyrrolidin-1-yl)-6-(trifluoromethyl)pyridine-3-carboxylic acid

HRID 607516노트

반응식

HRID 607516 반응식
Cl[C:2]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 27782102-Chloro-6-(trifluoromethyl)nicotinic acid

생성물 1

HCID 670469932-(Pyrrolidin-1-yl)-6-(trifluoromethyl)pyridine-3-carboxylic acid수율 95.2%

실험 절차

A mixture of 2-chloro-6-(trifluoromethyl)nicotinic acid (purchased from APOLLO, 5.0 g, 22.2 mmol) and pyrrolidine (40 ml, 562 mmol) was stirred for 24 hours at room temperature according to J. Med. Chem., 2005, 48, 71-90). Then the reaction mixture was evaporated in vacuo to give the title compound (5.5 g, 95%).

후처리

  1. customThen the reaction mixture was evaporated in vacuo

출처 및 근거

ORD 기록
ord-87abcd2e28c946149556c0a4c2b3e26e
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915448B2

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