反应详情

温度

0 °C

Hydrazine hydrate (1.50 mL, 0.0308 mol) was added to suspension of 3-chloro-6-phenyl-1,2,4-triazine (2.20 g, 0.0115 mol) in pyridine (12.0 mL) at 0° C. and stirred at 0° C. until a precipitate formed. The mixture was then heated at 65° C. for 30 min. The solvent was evaporated under reduced pressure. The residue was triturated with water, filtered, and washed with water. The crystalline formed was collected and dried under high vacuum to give the desired product (2.0 g, 93%). Analytical LCMS: (M+H)+=188.1.

1. customformed
2. temperatureThe mixture was then heated at 65° C. for 30 min
3. customThe solvent was evaporated under reduced pressure
4. customThe residue was triturated with water
5. filtrationfiltered
6. washwashed with water
7. customThe crystalline formed
8. customwas collected
9. customdried under high vacuum