反应详情

A mixture of methyl 4-(oxoacetyl)benzoate (13.5 g, 0.0702 mol), ethyl orthoformate (29 mL, 0.18 mol), p-toluenesulfonic acid monohydrate (0.7 g) in toluene (150 mL) was heated under reflux for 2 h. After cooling, the solvent was removed under reduced pressure. The crude material was flash chromatographed on a silica gel column to afford the desired product (15.4 g, 82%). Analytical LCMS: (M+Na)+=289.0.

1. temperaturewas heated
2. temperatureunder reflux for 2 h
3. temperatureAfter cooling
4. customthe solvent was removed under reduced pressure
5. customchromatographed on a silica gel column