反应详情

温度

0 °C

rac-cis-1-(4-Methoxybenzyl)-3-methylpiperidine-2-carboxamide (0.61 g, 2.33 mmol) was added portionwise to a suspension of LiAlH4 (0.30 g, 7.50 mmol) and THF (12 mL) and heated to reflux for 14 h. The reaction mixture was then cooled to 0° C. and quenched with water and NaOH (aq.). The resulting mixture was stirred at rt for 1 h, filtered and the filtrated was concentrated in vacuo to provide rac-cis-(1-(4-methoxybenzyl)-3-methylpiperidin-2-yl)methanamine as a colorless oil, used as-is without further purification.

1. temperatureheated
2. temperatureto reflux for 14 h
3. customquenched with water and NaOH (aq.)
4. filtrationfiltered
5. concentrationthe filtrated was concentrated in vacuo