HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60803Generated: October 27, 2026
2-Chlorobenzoxazole → rac-cis-(2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone
https://huagongshe.com/reaction/60803
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorobenzoxazole | HCID 11986 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 117727897 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | rac-cis-(2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 117728051 | — |
Reaction Steps
A mixture of rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 2-chlorobenzoxazole, and DIPEA in CH2Cl2 was stirred at 60° C. overnight. The reaction mixture was concentrated in vacuo to leave a near colorless solid. This solid was triturated with Et2O/hex to leave the title compound as a colorless solid homogeneous by HPLC analysis. MS (ESI) 465.03 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09440982B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-56083ee3773f4dfe9c0794f65fd1123d |
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| Source note | uspto-grants-2016_09 |
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