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HRID60803

反应详情

EQUATION

反应方程式

HRID 60803 的结构方程式

REACTANTS

反应物

3
结构：Clc1nc2ccccc2o1
HCID11986

Benzoxazole, 2-chloro-

C7H4ClNO

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：Cc1nc(C(=O)N2CCC[C@H](C)[C@@H]2CN)c(-c2ccc(F)cc2)s1
HCID117727897

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc(C(=O)N2CCC[C@H](C)[C@@H]2CNc2nc3ccccc3o2)c(-c2ccc(F)cc2)s1
HCID117728051

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

A mixture of rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 2-chlorobenzoxazole, and DIPEA in CH2Cl2 was stirred at 60° C. overnight. The reaction mixture was concentrated in vacuo to leave a near colorless solid. This solid was triturated with Et2O/hex to leave the title compound as a colorless solid homogeneous by HPLC analysis. MS (ESI) 465.03 (M+H).

WORKUP

后处理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto leave a near colorless solid
  3. customThis solid was triturated with Et2O/hex