3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → Biphenyl

HRID 608207Notes

Reaction equation

HRID 608207 reaction equation
CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CN1C(=O)C[C@@](C)(c2sccc2Cl)N/C1=N/C(=O)OC(C)(C)C.Cc1cc(O)ccc1B1OC(C)(C)C(C)(C)O1>CN(C)c1ccc([PH](C(C)(C)C)(C(C)(C)C)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)cc1.CS(C)=O.O>Cc1cc(O)ccc1-c1ccsc1[C@]1(C)CC(=O)N(C)/C(=N\C(=O)OC(C)(C)C)N1

Participants

9

Reactant 2

HCID 574432723-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 178481525HCID 178481525, compound

Product 3

HCID 7095BiphenylHCID 178428970HCID 178428970, compoundHCID 178481525HCID 178481525, compound

Reagents, catalysts & solvents 4

HCID 178482905HCID 178482905, compoundCatalystHCID 679Dimethyl SulfoxideSolvent4×HCID 962WaterSolventHCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineOther

Workup

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

Sources & evidence

ORD record
ord-8023f6fdbd414b5ab37a52db172c50d9
Source dataset
Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
Original link
View source

Reaction notes

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