5-(3-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → Methyl 1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5,5-dimethoxypiperidine-2-carboxylate

HRID 60825Notes

Reaction equation

HRID 60825 reaction equation
[CH3:1][O:2][C:3]1([O:13][CH3:14])[CH2:8][NH:7][CH:6]([C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:4]1.[F:15][C:16]1[CH:17]=[C:18]([C:22]2[S:26][C:25]([CH3:27])=[N:24][C:23]=2[C:28](O)=[O:29])[CH:19]=[CH:20][CH:21]=1>>[F:15][C:16]1[CH:17]=[C:18]([C:22]2[S:26][C:25]([CH3:27])=[N:24][C:23]=2[C:28]([N:7]2[CH2:8][C:3]([O:13][CH3:14])([O:2][CH3:1])[CH2:4][CH2:5][CH:6]2[C:9]([O:11][CH3:12])=[O:10])=[O:29])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 574371745-(3-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 89739337Methyl 5,5-dimethoxypiperidine-2-carboxylate

Product 1

HCID 89739507Methyl 1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5,5-dimethoxypiperidine-2-carboxylate

Procedure

Methyl 1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5,5-dimethoxypiperidine-2-carboxylate was prepared according to general procedure A using product methyl 5,5-dimethoxypiperidine-2-carboxylate and 5-(3-fluorophenyl)-2-methylthiazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-2450f20f22a4490f8cb23fc37cf78f8b
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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