5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → (5,5-Diethoxy-2-(hydroxymethyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

HRID 60830Notes

Reaction equation

HRID 60830 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14]([OH:16])=O)=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20]1([O:28][CH2:29][CH3:30])[CH2:25][NH:24][CH:23]([CH2:26][OH:27])[CH2:22][CH2:21]1)[CH3:18]>>[CH2:29]([O:28][C:20]1([O:19][CH2:17][CH3:18])[CH2:25][N:24]([C:14]([C:9]2[N:10]=[C:11]([CH3:13])[S:12][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:16])[CH:23]([CH2:26][OH:27])[CH2:22][CH2:21]1)[CH3:30]

Participants

3

Reactant 2

HCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 897391725,5-Diethoxy-2-piperidinemethanol

Product 1

HCID 89739753(5,5-Diethoxy-2-(hydroxymethyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Procedure

The title compound was prepared according to general procedure A using 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid and rac-(5,5-diethoxypiperidin-2-yl)methanol.

Sources & evidence

ORD record
ord-859d49219113445987c5fbc547119079
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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