5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → tert-Butyl (1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methylcarbamate

HRID 60833Notes

Reaction equation

HRID 60833 reaction equation
[CH3:1][CH:2]1[NH:7][CH:6]([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:5][CH2:4][CH2:3]1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[S:28][C:27]([CH3:29])=[N:26][C:25]=2[C:30](O)=[O:31])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[S:28][C:27]([CH3:29])=[N:26][C:25]=2[C:30]([N:7]2[CH:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH:6]2[CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:31])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 62321238Tert-butyl (6-methylpiperidin-2-yl)methylcarbamate

Product 1

HCID 89748251tert-Butyl (1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methylcarbamate

Procedure

rac-tert-Butyl (1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methylcarbamate was prepared according to general procedure A using rac-tert-butyl (6-methylpiperidin-2-yl)methylcarbamate and 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-1ebba1e104714efd819654560406491c
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

Loading…