反应详情

温度

70 °C

A mixture of rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 2-chloro-5-methoxypyrimidine, Pd2dba3, BINAP, and NaOtBu in toluene was purged with argon, and then stirred at 70° C. for 72 h. The reaction was cooled, filtered through a pad of silica gel and concentrated in vacuo. The crude reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound. MS (ESI) 456.2 (M+H).

1. customwas purged with argon
2. temperatureThe reaction was cooled
3. filtrationfiltered through a pad of silica gel
4. concentrationconcentrated in vacuo
5. customThe crude reaction mixture
6. customwas purified by reverse-phase preparative HPLC