3-Methoxypyridine-2-carbonitrile → rac-cis-(2-(Aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

HRID 60848Notes

Reaction equation

HRID 60848 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:9]#[N:10])=[N:5][CH:6]=[CH:7][CH:8]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[S:22][C:21]([CH3:23])=[N:20][C:19]=2[C:24](O)=[O:25])=[CH:14][CH:13]=1>>[NH2:10][CH2:9][C@H:4]1[C@@H:3]([O:2][CH3:1])[CH2:8][CH2:7][CH2:6][N:5]1[C:24]([C:19]1[N:20]=[C:21]([CH3:23])[S:22][C:18]=1[C:15]1[CH:16]=[CH:17][C:12]([F:11])=[CH:13][CH:14]=1)=[O:25]

Participants

3

Reactant 2

HCID 113324933-Methoxypyridine-2-carbonitrileHCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid

Product 1

HCID 131737138rac-cis-(2-(Aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Procedure

The title compound was synthesized following the same general protocol as described in Example 11 using 3-methoxypicolinonitrile and 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid. MS (ESI) 464.4 (M+H)

Sources & evidence

ORD record
ord-b868261d2ed44473a5c475e4b4067c5d
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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