Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60848Generated: October 29, 2026

3-Methoxypyridine-2-carbonitrile → rac-cis-(2-(Aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

https://huagongshe.com/reaction/60848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methoxypyridine-2-carbonitrileHCID 11332493—
Reactant5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 22324125—
Productrac-cis-(2-(Aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanoneHCID 131737138—

Reaction Steps

The title compound was synthesized following the same general protocol as described in Example 11 using 3-methoxypicolinonitrile and 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid. MS (ESI) 464.4 (M+H)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-b868261d2ed44473a5c475e4b4067c5d
Source noteuspto-grants-2016_09