2-Chlorobenzothiazole → rac-cis-(2-((Benzo[d]thiazol-2-ylamino)methyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

HRID 60850Notes

Reaction equation

HRID 60850 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][CH2:12][C@H:13]1[C@@H:18]([O:19][CH3:20])[CH2:17][CH2:16][CH2:15][N:14]1[C:21]([C:23]1[N:24]=[C:25]([CH3:35])[S:26][C:27]=1[C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)=[O:22]>>[S:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH:11][CH2:12][C@H:13]1[C@@H:18]([O:19][CH3:20])[CH2:17][CH2:16][CH2:15][N:14]1[C:21]([C:23]1[N:24]=[C:25]([CH3:35])[S:26][C:27]=1[C:28]1[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=1)=[O:22]

Participants

3

Reactant 2

HCID 119872-ChlorobenzothiazoleHCID 131737138rac-cis-(2-(Aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Product 1

HCID 131737140rac-cis-(2-((Benzo[d]thiazol-2-ylamino)methyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Procedure

The title compound was prepared following the same general protocol as described for Example 12 using 2-chlorobenzothiazole and rac-cis-(2-(aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone. MS (ESI) 497.0 (M+H).

Sources & evidence

ORD record
ord-0291c95e36564445811bcb9c18d27a20
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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