3,5-Dimethylisoxazole-4-boronic acid pinacol ester → 2-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-methylbenzoic acid

HRID 60903Notes

Reaction equation

HRID 60903 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5](C2C=NN(C)C=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:17][C:18]1[C:22](B2OC(C)(C)C(C)(C)O2)=[C:21]([CH3:32])[O:20][N:19]=1>>[CH3:17][C:18]1[C:22]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:10][C:6]=2[C:7]([OH:9])=[O:8])=[C:21]([CH3:32])[O:20][N:19]=1

Participants

3

Reactant 2

HCID 27586563,5-Dimethylisoxazole-4-boronic acid pinacol esterHCID 811115005-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid

Product 1

HCID 532250212-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-methylbenzoic acid

Procedure

The title compound was synthesized following the same general protocol as described for 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid in Example A1, using 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole. ESI-MS (m/z): 232 [M+1]+.

Sources & evidence

ORD record
ord-abe873709b86499fab59cf31e0553ee2
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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