5-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid → 5-Methyl-2-(2-methyl-4-pyrimidinyl)benzoic acid

HRID 60937Notes

Reaction equation

HRID 60937 reaction equation
CC1C=CC(C2C=NN(C)C=2)=C(C=1)C(O)=O.[CH3:17][C:18]1[CH:19]=[CH:20][C:21]([C:28]2[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[N:29]=2)=[C:22]([CH:27]=1)[C:23]([O:25]C)=[O:24]>>[CH3:17][C:18]1[CH:19]=[CH:20][C:21]([C:28]2[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[N:29]=2)=[C:22]([CH:27]=1)[C:23]([OH:25])=[O:24]

Participants

3

Reactant 2

HCID 811115005-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acidHCID 117727652Methyl 5-methyl-2-(2-methylpyrimidin-4-yl)benzoate

Product 1

HCID 1177278255-Methyl-2-(2-methyl-4-pyrimidinyl)benzoic acid

Procedure

The title compound was synthesized following the same general protocol as described for 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid in Example A1, using methyl 5-methyl-2-(2-methylpyrimidin-4-yl)benzoate. ESI-MS (m/z): 229 [M+1]+.

Sources & evidence

ORD record
ord-6e36181d1104415e89eeae68ac9ca791
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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