2-Methylpyridine-4-boronic acid pinacol ester → 5-Methyl-2-(2-methylpyridin-4-yl)benzoic acid

HRID 60955Notes

Reaction equation

HRID 60955 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[CH:12]=NN(C)[CH:15]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:17][C:18]1C=C(B2OC(C)(C)C(C)(C)O2)C=[CH:20][N:19]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[CH:15]=[CH:20][N:19]=[C:18]([CH3:17])[CH:12]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 164142742-Methylpyridine-4-boronic acid pinacol esterHCID 811115005-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid

Product 1

HCID 1161700395-Methyl-2-(2-methylpyridin-4-yl)benzoic acid

Procedure

The title compound was synthesized following the same general protocol as described for 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid in Example A1, using 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. ESI-MS (m/z): 228 [M+1]+.

Sources & evidence

ORD record
ord-1d2509a6735c4ab7b67cc05919320bca
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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