反应详情

Sodium acetate (517 mg) and hydroxylamine hydrochloride (219 mg) are successively added to a methanol-methylene chloride solution (10--10 ml) of 1.00 g of the product of Step 2, and the mixture is stirred at room temperature for 2 days. The solvent is evaporated and the residue is dissolved in methanol, followed by addition of a silica gel (8 g). Methanol is evaporated and the residue is purified by silica gel column chromatography (solvent: chloroform/methanol=50/1-25/1) to afford the title compound.

1. customThe solvent is evaporated
2. dissolutionthe residue is dissolved in methanol
3. additionfollowed by addition of a silica gel (8 g)
4. customMethanol is evaporated
5. customthe residue is purified by silica gel column chromatography (solvent: chloroform/methanol=50/1-25/1)