4-Aminomethyl-1-N-butylpiperidine → N-[(1-n butyl-4-piperidyl)methyl] 5-fluoroindole-3-carboxamide

HRID 609603Notes

Reaction equation

HRID 609603 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11](Cl)=[O:12].[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH2:25])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]>>[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH:25][C:11]([C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][CH:6]=2)=[O:12])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]

Participants

3

Reactant 2

HCID 104421334-Aminomethyl-1-N-butylpiperidineHCID 543282495-Fluoroindole-3-carboxylic acid chloride

Product 1

HCID 53789030N-[(1-n butyl-4-piperidyl)methyl] 5-fluoroindole-3-carboxamideYield 64%

Procedure

5-Fluoroindole-3-carboxylic acid chloride was reacted with (1-n butyl-4-piperidyl)methylamine (Description 1a) as in the method of Description 1b to afford N-[(1-n butyl-4-piperidyl)methyl] 5-fluoroindole-3-carboxamide as an off-white solid (64%).

Sources & evidence

ORD record
ord-d0b509eb741e4c9ab71be7b32083aa20
Source dataset
uspto-grants-1999_12
Patent number
US05998409

Reaction notes

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