N-(2-Aminoethyl)piperidine → N-[2-(1-Piperidyl)ethyl] 1H-indole-3-carboxamide

HRID 609612Notes

Reaction equation

HRID 609612 reaction equation
[N:1]1([CH2:7][CH2:8][NH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([C:19](Cl)=[O:20])=[CH:11]1>>[N:1]1([CH2:7][CH2:8][NH:9][C:19]([C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][CH:11]=2)=[O:20])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 33944N-(2-Aminoethyl)piperidineHCID 123802781H-Indole-3-carbonyl chloride

Product 1

HCID 10635843N-[2-(1-Piperidyl)ethyl] 1H-indole-3-carboxamide

Procedure

1-Piperidineethylamine was reacted with 1H-indole-3-carboxylic acid chloride using the method described in Description 1 to afford the title compound (D2) as a beige solid.

Sources & evidence

ORD record
ord-1a878120141342c99d35bd80246da004
Source dataset
uspto-grants-1999_12
Patent number
US05998409

Reaction notes

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