rac-(2R,3S)-1-[(benzyloxy)carbonyl]-3-methylpiperidine-2-carboxylic acid → 2-(((2R,3S)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dione
Reaction equation
[CH3:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C@@H:3]1[CH2:8][N:9]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]1=[O:19].C(OC(N1CCC[C@H](C)[C@@H]1C(O)=O)=O)C1C=CC=CC=1>>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C@H:3]1[CH2:8][N:9]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]1=[O:19]Participants
3
Procedure
The title compound was prepared following the same general protocol as described for 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione in Example A1 instead using (2R,3S)-1-((benzyloxy)carbonyl)-3-methylpiperidine-2-carboxylic acid. MS (ESI) 259 (M+H).
Sources & evidence
- ORD record
- ord-de9730aa9f8441c1b8f8d0ac40b6d2ee
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09440982B2
Reaction notes
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