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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60963Generated: October 30, 2026

rac-(2R,3S)-1-[(benzyloxy)carbonyl]-3-methylpiperidine-2-carboxylic acid → 2-(((2R,3S)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dione

https://huagongshe.com/reaction/60963

Reaction equation

Participants

RoleNameHCIDCharge
Reactantrac-(2R,3S)-1-[(benzyloxy)carbonyl]-3-methylpiperidine-2-carboxylic acidHCID 66624874—
Reactant2-(((2S,3R)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117727630—
Product2-(((2R,3S)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117727782—

Reaction Steps

The title compound was prepared following the same general protocol as described for 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione in Example A1 instead using (2R,3S)-1-((benzyloxy)carbonyl)-3-methylpiperidine-2-carboxylic acid. MS (ESI) 259 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-de9730aa9f8441c1b8f8d0ac40b6d2ee
Source noteuspto-grants-2016_09