(+-)-3-Quinuclidinol → HCID 15453400, compound

HRID 609634Notes

Reaction equation

HRID 609634 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([OH:9])[CH2:2]2.[C:10]1([CH3:19])[CH:15]=[CH:14][C:13]([N:16]=[C:17]=[O:18])=[CH:12][CH:11]=1>>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([O:9][C:17](=[O:18])[NH:16][C:13]1[CH:14]=[CH:15][C:10]([CH3:19])=[CH:11][CH:12]=1)[CH2:2]2

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 693254-Methylphenyl isocyanate

Product 1

HCID 15453400HCID 15453400, compoundYield 93%

Procedure

3-Quinuclidinol and 4-tolyl isocyanate were used. Filtration of the precipitated solid from the cooled reaction mixture afforded the title compound (93%) as a white solid: mp 186.0-187.5° C.; FAB LRMS m /z (relative intensity, %) 262 (21), 261 ([MH+ ], 100).

Workup

  1. filtrationFiltration of the precipitated solid
  2. customfrom the cooled reaction mixture

Sources & evidence

ORD record
ord-60f575926791426396557e5208a2edea
Source dataset
uspto-grants-1999_12
Patent number
US05998429

Reaction notes

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