5-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid → rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

HRID 60991Notes

Reaction equation

HRID 60991 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1C(C1N=C(C)SC=1C1C=CC(F)=CC=1)=O.[CH3:25][C:26]1[CH:27]=[CH:28][C:29]([C:35]2[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=2)=[C:30]([CH:34]=1)[C:31]([OH:33])=O>>[NH2:1][CH2:2][C@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:31]([C:30]1[CH:34]=[C:26]([CH3:25])[CH:27]=[CH:28][C:29]=1[C:35]1[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=1)=[O:33]

Participants

3

Reactant 2

HCID 811115005-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acidHCID 131737142rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Product 1

HCID 131737161rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Procedure

The title compound was prepared following the same general protocol as described for rac-trans-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone in Example A65 using 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid. MS (ESI) 327 (M+H).

Sources & evidence

ORD record
ord-18d3af9e58f3414db3f29252e12a17d6
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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