HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid → rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid | HCID 81111500 | — |
| Reactant | rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 131737142 | — |
| Product | rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone | HCID 131737161 | — |
Reaction Steps
The title compound was prepared following the same general protocol as described for rac-trans-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone in Example A65 using 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid. MS (ESI) 327 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440982B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-18d3af9e58f3414db3f29252e12a17d6 |
| Source note | uspto-grants-2016_09 |