反应详情

A solution of 2-((2-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)octahydrocyclopenta[c]pyrrol-1-yl)methyl)isoindoline-1,3-dione (1 equiv.) and hydrazine monohydrate (4 equiv.) in MeOH (0.5M) was stirred at 70° C. for 3 h and then concentrated in vacuo to a yellow oil. The reaction mixture was diluted with EtOAc and washed with water, brine, dried (MgSO4), and concentrated. The crude residue was purified by chromatography on silica gel (20% MeOH in EtOAc) to firstly remove the impurities and then (2:8:1 MeOH/EtOAc/TEA) to elute the title compound which was concentrated to yield a yellow oil. MS (ESI) 326 (M+H).

1. concentrationconcentrated in vacuo to a yellow oil
2. additionThe reaction mixture was diluted with EtOAc
3. washwashed with water, brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customThe crude residue was purified by chromatography on silica gel (20% MeOH in EtOAc)
7. customto firstly remove the impurities
8. wash(2:8:1 MeOH/EtOAc/TEA) to elute the title compound which
9. concentrationwas concentrated
10. customto yield a yellow oil