Ethanol → HCID 21705551, compound

HRID 610030Notes

Reaction equation

HRID 610030 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Br[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].O.C(=O)([O-])[O-].[Na+].[Na+].[CH2:27](O)[CH3:28]>>[N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[NH:6][C:2]=1[S:1][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:27][CH3:28])=[O:18]

Participants

6

Reactant 5

HCID 702EthanolHCID 962WaterHCID 10340Sodium CarbonateHCID 202106-Bromohexanoic acidHCID 178527775HCID 178527775, compound

Product 1

HCID 21705551HCID 21705551, compound

Procedure

2-Mercaptobenzimidazole (6.3 g) and 6-bromocaproic acid (7.8 g) were dissolved in ethanol (35 ml), and the solution ws heated under reflux for 12 hours. After cooling, the reaction was added with water, and the mixture was adjusted to pH 8 with aqueous sodium carbonate. The deposited crystals were collected by filtration, and dried to obtain 11.2 g of the title compound.

Workup

  1. temperaturethe solution ws heated
  2. temperatureunder reflux for 12 hours
  3. temperatureAfter cooling
  4. filtrationThe deposited crystals were collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-7b171e35f35b4a2b8173ae3837c37287
Source dataset
uspto-grants-1999_12
Patent number
US05998456

Reaction notes

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