HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-amino-N-(4-fluorophenyl)benzamide → 5-Acetyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-fluoro-phenylcarbamoyl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-amino-N-(4-fluorophenyl)benzamide | HCID 16477034 | — |
| Reactant | 1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester | HCID 53893352 | — |
| Product | 5-Acetyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-fluoro-phenylcarbamoyl)-phenyl]-amide | HCID 9955841 | — |
Reaction Steps
Prepared as in Example 1 from 1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester and 3-amino-N-(4-fluoro-phenyl)-benzamide. Recrystallized from ethyl acetate-hexanes-benzene. Calculated for C26H22FN3O4 : C 67.97; H 4.83; N 9.15; found C 68.34; H 5.31; N 8.80.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998463 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-4e61774953224f4b945feb603c693ad9 |
| Source note | uspto-grants-1999_12 |