HRID610068

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13609514

未命名化合物

结构：CCOC(=O)C1C(=O)N(CC)c2ccc(C(=O)c3ccccc3)cc21

HCID20189466

未命名化合物

PRODUCTS

生成物

结构：CCN1C(=O)C(C(=O)Nc2cccc(C(=O)Nc3ccc(Br)cc3)c2)c2cc(C(=O)c3ccccc3)ccc21

HCID54177968

未命名化合物

PROCEDURE

实验过程

Prepared as in Example 1, Step A, from 5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester (U.S. Pat. No. 4,686,224) and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1) followed by trituration in ethyl acetate/hexanes. mp 139-142° C.

WORKUP

后处理

customPrepared as in Example 1, Step A
customPurified by flash-chromatography (hexanes/acetone, 1:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5135fb3f47c14e0582bed7be8351239d
来源数据集: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05998463
来源说明: uspto-grants-1999_12

反应 SMILES

C(O[C:4]([CH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:13]=2)[N:8]([CH2:23][CH3:24])[C:7]1=[O:25])=[O:5])C.[NH2:26][C:27]1[CH:28]=[C:29]([CH:40]=[CH:41][CH:42]=1)[C:30]([NH:32][C:33]1[CH:38]=[CH:37][C:36]([Br:39])=[CH:35][CH:34]=1)=[O:31]>>[Br:39][C:36]1[CH:37]=[CH:38][C:33]([NH:32][C:30]([C:29]2[CH:28]=[C:27]([NH:26][C:4]([CH:6]3[C:14]4[C:9](=[CH:10][CH:11]=[C:12]([C:15](=[O:22])[C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=5)[CH:13]=4)[N:8]([CH2:23][CH3:24])[C:7]3=[O:25])=[O:5])[CH:42]=[CH:41][CH:40]=2)=[O:31])=[CH:34][CH:35]=1