HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-N-(4-bromophenyl)benzamide → 5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-N-(4-bromophenyl)benzamide | HCID 13609514 | — |
| Reactant | Ethyl 1-ethyl-5-benzoyloxindole-3-carboxylate | HCID 20189466 | — |
| Product | 5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide | HCID 54177968 | — |
Reaction Steps
Prepared as in Example 1, Step A, from 5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester (U.S. Pat. No. 4,686,224) and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1) followed by trituration in ethyl acetate/hexanes. mp 139-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05998463 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-5135fb3f47c14e0582bed7be8351239d |
| Source note | uspto-grants-1999_12 |