3-Fluoro-2-methoxybenzoic acid → ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(3-fluoro-2-methoxyphenyl)methanone

HRID 61007Notes

Reaction equation

HRID 61007 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[F:25][C:26]1[C:27]([O:35][CH3:36])=[C:28]([CH:32]=[CH:33][CH:34]=1)[C:29]([OH:31])=O>>[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:29]([C:28]1[CH:32]=[CH:33][CH:34]=[C:26]([F:25])[C:27]=1[O:35][CH3:36])=[O:31]

Participants

3

Reactant 2

HCID 27373613-Fluoro-2-methoxybenzoic acidHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727693((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(3-fluoro-2-methoxyphenyl)methanone

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 3-fluoro-2-methoxybenzoic acid. MS (ESI) 281 (M+H).

Sources & evidence

ORD record
ord-f3b857c1da634f24a69ef3561630252c
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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